表1 铁死亡的诱导剂与抑制剂[1~4]

1、自噬通过铁蛋白降解调控铁死亡

铁死亡最近被描述为一种自噬性细胞死亡过程，自噬通过调节细胞内铁稳态和活性氧产生，在诱导铁死亡发生过程中发挥核心作用[5]。

2、铁死亡调控因子被转运至溶酶体中，并通过自噬过程执行其功能

Keap-NRF2信号通路可能是铁死亡与自噬之间的重要联系[6-7]。RNA结合蛋白ELAVL1/HuR在调节肝纤维化铁死亡中起到重要作用[8]，铁死亡诱导剂通过抑制泛素蛋白酶体途径提高ELAVL1蛋白水平，同时下调ELAVL1蛋白能促进自噬体产生。Beclin-1通过与SLC7A11直接相互作用，诱导脂质过氧化并通过阻断System Xc-的活性来促进铁死亡[9]。p53激活抑制mTOR活性，随后促进自噬发生[10]；最近还发现核p53以转录依赖的方式刺激铁死亡，通过抑制编码System Xc-的基因SLC7A11的表达，抑制胱氨酸摄取和细胞对铁死亡的敏感性。

Fig. 4[4] 铁死亡与自噬的交互作用示意图  A：铁死亡与自噬交互作用的总体机制 B：p53在铁死亡与自噬交互作用中的作用 C：Beclin-1在铁死亡与自噬交互作用中的作用 D：在铁死亡与自噬交互作用当中涉及到的其他关键分子和通路

3、癌症耐药中细胞自噬与铁死亡的相互关系

Fig. 5[4]  自噬与铁死亡在耐药中微调转换

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